VI FP - Life Sciences, 2004-2007 Programmed cell death across the eukaryotic kingdoms (TRANSDEATH) The Objectives The TransDeath project will focus on cellular and molecular events in less known cell death types. Thus, the project aims to broaden the experimental net to catch PCD regulators by comparative research on diverse organisms, each uniquely suited to unravel a type of conserved PCD process. The main approach will be across the eukaryotic kingdom, the main aim will be understanding different types of cell death in humans. TransDeath thereby aims to produce knowledge on genes and biochemical processes that regulate PCD in different organisms, and to apply that knowledge to develop strategies and targets for human disease therapy

Laboratory of signal transduction

VI FP - Life Sciences, 2004-2007

Programmed cell death across the eukaryotic kingdoms (TRANSDEATH)

The Objectives

The TransDeath project will focus on cellular and molecular events in less known cell death types. Thus, the project aims to broaden the experimental net to catch PCD regulators by comparative research on diverse organisms, each uniquely suited to unravel a type of conserved PCD process. The main approach will be across the eukaryotic kingdom, the main aim will be understanding different types of cell death in humans. TransDeath thereby aims to produce knowledge on genes and biochemical processes that regulate PCD in different organisms, and to apply that knowledge to develop strategies and targets for human disease therapy

FUNDED EUROPEAN PROJECTS

The Partnership

V FP - Quality of Life, 2001-2004

Molecular mechanisms of senescence and ageing (CELLAGE)

The Objectives

The goal of this project is to define determinants of healthy ageing and use this knowledge to understand age-related disfunctions, with the ultimate goal to develop new strategies for their prevention and treatment.

The Partnership

IV FP - Training and Mobility of Researchers, 1998-2001

Regulation of apoptosis in tissue homeostasis and cancer: the role of TNF-R1 and Fas/APO-1

The Objectives

The goal of this project is to characterize the molecular pathways bringing the signals generated from the human TNF-R1 and Fas/APO-1 receptors down to the effectors of the apoptotic response in tumor cells.

The Partnership

IV FP - Biomed 2, 1996-1999

Surface receptor-induced apoptosis in trasformed cells: defining the molecular events involved in TNFR-1 and Fas/APO-1 -induced apoptotic signaling

The Objectives

The Partnership

III FP - Human Capital and Mobility, 1995-1998

Signal transduction mechanisms that control the activation, growth and apoptosis of T lymphocytes

The Objectives

1) To examine the signal transduction mechanisms used by the T cell antigen receptor, the IL-1 receptor, the CD28 antigen and the CD69 antigen to induce T cell activation. 2) To examine the signal transduction mechanisms used by the IL-2 receptor and the Fas antigen to control T cell growth and apoptosis.

The Partnership

VII FP - European Research Coucil, Advanced Grant, 2011-2014

Friedreich Ataxia Seeks Therapy (FAST)

The Objectives

Our goal is two fold: 1) submit a set of leads we already identified, as well as their new and more complex derivatives, to preclinical testing in FRDA mice 2) identify the E3 ligase that is responsible for frataxin ubiquitination, and investigate the possibility to use it as a druggable target for small molecules to prevent frataxin degradation.

Horizon 2020 - European Research Coucil, Proof of Concept Grant, 2015-2016 - FAST-DEVELOPS

The Objectives

Aim of the project is to develop the intellectual property generated within the FAST project into a viable business endeavour.